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Novel Vaccine for Colorectal Cancer Shows Positive Phase I Results

Novel Vaccine for Colorectal Cancer Shows Positive Phase I Results

The vaccine proves safe in a small sample of human subjects, opening the way for the next phase of testing. PHILADELPHIA — A new colorectal cancer vaccine showed positive results in the phase 1 clinical trial to demonstrate that the approach is safe. The patients treated had no signs of serious adverse events and samples of their blood contained markers of immune activation — an early indication that the vaccine could activate immune [Read More...]
Scientists get sly, use deception to fight cancer

Scientists get sly, use deception to fight cancer

Hebrew University researchers create decoys that block RNA-binding proteins from spreading cancer. Meet oligonucleotide, the RNA-binding decoy molecule. Credit: Rotem Karni In recent years, it’s become clear that RNA-binding proteins play a major role in cancer growth. These proteins, active in all cells but especially so in cancer cells, bind to RNA molecules and accelerate cancer cell growth. Unfortunately, no cancer treatment has [Read More...]
Turning silenced cancer genes back into fighters

Turning silenced cancer genes back into fighters

Targeting protein known as UHRF1 may shrink tumors by restoring aberrant gene regulation in cancer cells. Working with human colon cancer cells and mice, researchers led by experts at the Johns Hopkins Kimmel Cancer Center say they have successfully blocked the activity of portions of a protein known as UHRF1 and restored the function of hundreds of cancer-fighting genes that became “misregulated” by the disease. Credit: Johns [Read More...]

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